Bulk Sermorelin
GHRH fragment and pituitary signaling research research material, supplied as a lyophilized reference standard. >=99% by HPLC.
Available Sizes & Pricing
| Size | Price per vial (USD) |
|---|---|
| 5 mg | $69.95 |
| 10 mg | $109.95 |
A minimum inquiry quantity of 10 vials applies across requested products. Inquire for bulk purchase or larger lot quantities →
Bulk Sermorelin Specifications
| CAS Number | 86168-78-7 |
|---|---|
| Molecular Formula | C149H246N44O42S |
| Molecular Weight | 3357.9 g/mol |
| Purity | >=99% by HPLC |
| Storage | Store lyophilized material at -20 C. Avoid repeated freeze-thaw cycles after reconstitution. |
What Is Sermorelin?
Sermorelin is cataloged for controlled laboratory workflows focused on ghrh fragment and pituitary signaling research. Its lot-specific analytical documentation should be reviewed alongside the receiving laboratory's established handling and assay-validation procedures. For laboratory research use only - not for human or veterinary use.
Sermorelin Research Context
Sermorelin is a synthetic 29-amino-acid peptide corresponding to the biologically active N-terminal fragment of endogenous growth-hormone-releasing hormone (GHRH 1-29). It retains full GHRH receptor (GHRHR) binding capacity relative to the full 44-residue sequence, making it a compact tool compound for pituitary cell receptor assays. Its well-defined primary sequence and commercially available analytical standards support use in method-validation workflows.
Sermorelin binds GHRHR and activates Gs-coupled adenylyl cyclase, raising intracellular cAMP in GHRHR-expressing cells. Unlike ipamorelin and other GHSRs, it operates through the GHRH axis rather than the ghrelin axis, allowing axis-specific dissection of upstream somatotropic signaling.
Study-Design Considerations
- Sermorelin is susceptible to rapid degradation by dipeptidyl peptidase IV (DPP-IV) in serum-containing media; use DPP-IV inhibitors or serum-free conditions to maintain active peptide concentrations during extended incubations.
- Because GHRHR density varies widely across cell lines, pilot experiments with dose-response curves (1 nM–1 µM) are recommended before committing to fixed-concentration assay plates.
Interpretation Limits
cAMP signals measured in GHRHR-transfected cell lines may overestimate receptor sensitivity relative to primary pituitary cells where receptor and G-protein stoichiometry differs.
Sermorelin Research Applications
- GHRH receptor assays
- Pituitary cell research
- Growth-hormone axis studies
Source Records
Use the following scientific and compound-record sources when developing a laboratory-specific protocol; they do not replace method validation for a particular lot or assay.
Related Research Materials
- Bulk Ipamorelin — ghrelin receptor and growth-hormone secretagogue research research material, supplied as a lyophilized reference standard. >=99% by HPLC.
- Bulk Tesamorelin — GHRH analog and growth-hormone axis research research material, supplied as a lyophilized reference standard. >=99% by HPLC.
Buy Bulk Sermorelin for Research
Bulk Peptides supplies bulk Sermorelin to institutional laboratories, CROs, and research facilities across the United States. Every lot is characterized by reverse-phase HPLC at 220 nm and confirmed by electrospray ionization mass spectrometry before shipping. A lot-specific Certificate of Analysis documents both results for your records.
Bulk Sermorelin is available in the catalog sizes above. A minimum inquiry quantity of 10 vials applies; contact us for larger requirements or custom synthesis quotes. All products are for laboratory research use only (RUO) — not for human or veterinary use.
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