Bulk PT-141
melanocortin receptor pharmacology research material, supplied as a lyophilized reference standard. >=99% by HPLC.
Available Sizes & Pricing
| Size | Price per vial (USD) |
|---|---|
| 10 mg | $49.95 |
A minimum inquiry quantity of 10 vials applies across requested products. Inquire for bulk purchase or larger lot quantities →
Bulk PT-141 Specifications
| CAS Number | See lot-specific COA |
|---|---|
| Molecular Formula | See lot-specific COA |
| Molecular Weight | See lot-specific COA |
| Purity | >=99% by HPLC |
| Storage | Store lyophilized material at -20 C. Avoid repeated freeze-thaw cycles after reconstitution. |
What Is PT-141?
PT-141 is cataloged for controlled laboratory workflows focused on melanocortin receptor pharmacology. Its lot-specific analytical documentation should be reviewed alongside the receiving laboratory's established handling and assay-validation procedures. For laboratory research use only - not for human or veterinary use.
PT-141 Research Context
PT-141 (bremelanotide; Ac-Nle⁴-cyclo[Asp⁵-His⁶-D-Phe⁷-Arg⁸-Trp⁹-Lys¹⁰]-OH) is a cyclic melanocortin peptide closely related to melanotan 2 but with a free C-terminal carboxyl group instead of an amide. In receptor pharmacology research it is used as an MC3R and MC4R preferential agonist, making it a useful comparator to MT-2 for investigating how C-terminal modification affects receptor-subtype selectivity and downstream cAMP responses.
Like MT-2, PT-141 activates melanocortin receptors through Gs-coupled cAMP production. The carboxylate versus amide C-terminus alters binding affinity profiles at individual receptor subtypes, which researchers exploit in selectivity-ranking studies. MC4R-mediated signaling downstream of PT-141 has been characterized in hypothalamic cell models.
Study-Design Considerations
- Prepare fresh working dilutions from the lyophilized stock each assay day; the free carboxylic acid C-terminus makes PT-141 more susceptible to aspartyl bond hydrolysis at elevated temperature compared with the amidated MT-2.
- Side-by-side EC₅₀ curves for PT-141 and MT-2 on the same receptor panel are the most informative experimental design for resolving C-terminal effects on potency.
Interpretation Limits
Selectivity ratios obtained in transfected HEK293 cells may differ substantially from receptor pharmacology in native neuronal cells where receptor accessory proteins and downstream signaling contexts are different.
PT-141 Research Applications
- MC receptor binding assays
- Neuropeptide pathway research
- Signal transduction studies
Source Records
Use the following scientific and compound-record sources when developing a laboratory-specific protocol; they do not replace method validation for a particular lot or assay.
Related Research Materials
- Bulk Melanotan 2 — melanocortin receptor research research material, supplied as a lyophilized reference standard. >=99% by HPLC.
- Bulk Kisspeptin-10 — kisspeptin receptor and neuroendocrine signaling research research material, supplied as a lyophilized reference standard. >=99% by HPLC.
Buy Bulk PT-141 for Research
Bulk Peptides supplies bulk PT-141 to institutional laboratories, CROs, and research facilities across the United States. Every lot is characterized by reverse-phase HPLC at 220 nm and confirmed by electrospray ionization mass spectrometry before shipping. A lot-specific Certificate of Analysis documents both results for your records.
Bulk PT-141 is available in the catalog sizes above. A minimum inquiry quantity of 10 vials applies; contact us for larger requirements or custom synthesis quotes. All products are for laboratory research use only (RUO) — not for human or veterinary use.
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