Bulk Melanotan 2
melanocortin receptor research research material, supplied as a lyophilized reference standard. >=99% by HPLC.
Available Sizes & Pricing
| Size | Price per vial (USD) |
|---|---|
| 10 mg | $69.95 |
A minimum inquiry quantity of 10 vials applies across requested products. Inquire for bulk purchase or larger lot quantities →
Bulk Melanotan 2 Specifications
| CAS Number | See lot-specific COA |
|---|---|
| Molecular Formula | See lot-specific COA |
| Molecular Weight | See lot-specific COA |
| Purity | >=99% by HPLC |
| Storage | Store lyophilized material at -20 C. Avoid repeated freeze-thaw cycles after reconstitution. |
What Is Melanotan 2?
Melanotan 2 is cataloged for controlled laboratory workflows focused on melanocortin receptor research. Its lot-specific analytical documentation should be reviewed alongside the receiving laboratory's established handling and assay-validation procedures. For laboratory research use only - not for human or veterinary use.
Melanotan 2 Research Context
Melanotan 2 (MT-2; Ac-Nle⁴-cyclo[Asp⁵-His⁶-D-Phe⁷-Arg⁸-Trp⁹-Lys¹⁰]-NH₂) is a cyclic synthetic analog of α-MSH designed to enhance melanocortin receptor binding through cyclization of the central pharmacophore. In receptor pharmacology research it is used as a broad melanocortin receptor agonist (MC1R, MC3R, MC4R, MC5R) that provides a non-linear binding footprint compared with the linear α-MSH sequence. It is a common reference compound in competitive radioligand displacement assays across melanocortin receptor subtypes.
The lactam bridge cyclization in MT-2 constrains the His-Phe-Arg-Trp core motif into a receptor-preferred conformation, increasing binding affinity at MC3R and MC4R relative to linear ACTH/MSH fragments. In cell-based signaling assays, MC4R activation by MT-2 produces cAMP accumulation through Gs coupling.
Study-Design Considerations
- Melanotan 2 contains a disulfide-independent lactam bridge; reducing agents in cell culture media do not affect its cyclic conformation, but oxidizing conditions can affect the Trp residue—verify integrity by LC-MS before use.
- When running multi-receptor selectivity panels, include selective receptor-subtype antagonists (e.g., SHU-9119 for MC3R/MC4R) alongside MT-2 to deconvolute receptor-specific contributions to observed cAMP signals.
Interpretation Limits
The pan-melanocortin receptor activity of MT-2 in cell-based assays limits mechanistic specificity; studies requiring single-receptor resolution should use receptor-subtype-selective analogs or CRISPR-edited receptor-null lines.
Melanotan 2 Research Applications
- Melanocortin receptor assays
- Ligand-binding studies
- Signal transduction research
Source Records
Use the following scientific and compound-record sources when developing a laboratory-specific protocol; they do not replace method validation for a particular lot or assay.
Related Research Materials
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Buy Bulk Melanotan 2 for Research
Bulk Peptides supplies bulk Melanotan 2 to institutional laboratories, CROs, and research facilities across the United States. Every lot is characterized by reverse-phase HPLC at 220 nm and confirmed by electrospray ionization mass spectrometry before shipping. A lot-specific Certificate of Analysis documents both results for your records.
Bulk Melanotan 2 is available in the catalog sizes above. A minimum inquiry quantity of 10 vials applies; contact us for larger requirements or custom synthesis quotes. All products are for laboratory research use only (RUO) — not for human or veterinary use.
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