Bulk NAD+
redox, mitochondrial, and cellular energy research research material, supplied as a lyophilized reference standard. >=98% by HPLC.
Available Sizes & Pricing
| Size | Price per vial (USD) |
|---|---|
| 500 mg | $99.95 |
| 1000 mg | $159.95 |
A minimum inquiry quantity of 10 vials applies across requested products. Inquire for bulk purchase or larger lot quantities →
Bulk NAD+ Specifications
| CAS Number | See lot-specific COA |
|---|---|
| Molecular Formula | See lot-specific COA |
| Molecular Weight | See lot-specific COA |
| Purity | >=98% by HPLC |
| Storage | Store dry material at -20 C and protect from light and moisture. |
What Is NAD+?
NAD+ is cataloged for controlled laboratory workflows focused on redox, mitochondrial, and cellular energy research. Its lot-specific analytical documentation should be reviewed alongside the receiving laboratory's established handling and assay-validation procedures. For laboratory research use only - not for human or veterinary use.
NAD+ Research Context
NAD⁺ (nicotinamide adenine dinucleotide) is an essential pyridine nucleotide cofactor present in all living cells, where it participates in redox reactions and serves as a substrate for sirtuins, PARP enzymes, and CD38/CD157 ecto-enzymes. As a research reference material, NAD⁺ is used in biochemical assays that measure SIRT1/SIRT3 deacetylase activity, PARP-1 ribosylation kinetics, and intracellular NAD⁺/NADH ratio changes in cellular energy-metabolism models.
NAD⁺ acts as a hydride acceptor in glycolysis, the TCA cycle, and beta-oxidation. As a substrate for sirtuin deacylases, it is cleaved to yield nicotinamide and ADP-ribose during protein deacetylation, coupling metabolic state to epigenetic regulation. Researchers exploit this mechanistic link to examine how NAD⁺ availability influences sirtuin-dependent gene-expression programs.
Study-Design Considerations
- NAD⁺ is hygroscopic and light-sensitive; aliquot dry powder into single-use amounts under inert atmosphere and store at -20 °C in the dark to prevent non-enzymatic hydrolysis to NAM and ADP-ribose.
- Extracellular NAD⁺ supplementation experiments require careful distinction between direct intracellular uptake and receptor-mediated (P2Y, CD38) extracellular effects; use cell-impermeable analogs as controls where mechanistic clarity is needed.
Interpretation Limits
Exogenous NAD⁺ addition to culture media does not accurately model intracellular NAD⁺ compartmentalization; enzymatic assays performed with purified proteins more cleanly isolate specific mechanistic endpoints.
NAD+ Research Applications
- Redox pathway assays
- Mitochondrial research
- Enzyme cofactor studies
Source Records
Use the following scientific and compound-record sources when developing a laboratory-specific protocol; they do not replace method validation for a particular lot or assay.
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Buy Bulk NAD+ for Research
Bulk Peptides supplies bulk NAD+ to institutional laboratories, CROs, and research facilities across the United States. Every lot is characterized by reverse-phase HPLC at 220 nm and confirmed by electrospray ionization mass spectrometry before shipping. A lot-specific Certificate of Analysis documents both results for your records.
Bulk NAD+ is available in the catalog sizes above. A minimum inquiry quantity of 10 vials applies; contact us for larger requirements or custom synthesis quotes. All products are for laboratory research use only (RUO) — not for human or veterinary use.
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