Bulk MOTS-c
mitochondrial-derived peptide and metabolic signaling research research material, supplied as a lyophilized reference standard. >=99% by HPLC.
Available Sizes & Pricing
| Size | Price per vial (USD) |
|---|---|
| 10 mg | $64.95 |
| 40 mg | $169.95 |
A minimum inquiry quantity of 10 vials applies across requested products. Inquire for bulk purchase or larger lot quantities →
Bulk MOTS-c Specifications
| CAS Number | See lot-specific COA |
|---|---|
| Molecular Formula | See lot-specific COA |
| Molecular Weight | See lot-specific COA |
| Purity | >=99% by HPLC |
| Storage | Store lyophilized material at -20 C. Avoid repeated freeze-thaw cycles after reconstitution. |
What Is MOTS-c?
MOTS-c is cataloged for controlled laboratory workflows focused on mitochondrial-derived peptide and metabolic signaling research. Its lot-specific analytical documentation should be reviewed alongside the receiving laboratory's established handling and assay-validation procedures. For laboratory research use only - not for human or veterinary use.
MOTS-c Research Context
MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene. It is proposed to function as a retrograde mitochondria-to-nucleus signaling peptide that modulates AMPK-dependent metabolic gene expression. As a research tool compound it is used in studies examining how mitochondrial peptide signals integrate with nuclear metabolic programs in skeletal muscle and liver cell models.
MOTS-c activates AMPK and downstream FOXO1/PGC-1α transcriptional programs in cell-based assays, with reported effects on glucose uptake through GLUT4 translocation in differentiated muscle cells. Its retrograde signaling role makes it conceptually distinct from classical nuclear-encoded peptides in mitochondrial-metabolic research.
Study-Design Considerations
- MOTS-c experiments in differentiated muscle cells require sufficient differentiation time (typically 5–7 days for C2C12 cells) before peptide addition to ensure myotube GLUT4 expression levels are appropriate for glucose-uptake readouts.
- Include compound C (AMPK inhibitor) parallel arms to confirm that observed metabolic effects are AMPK-dependent rather than attributable to off-pathway peptide activity.
Interpretation Limits
MOTS-c biology has been characterized predominantly in rodent cell lines; translation to human primary cells requires independent validation of the same signaling relationships.
MOTS-c Research Applications
- Mitochondrial signaling research
- Cellular energy models
- Metabolic pathway assays
Source Records
Use the following scientific and compound-record sources when developing a laboratory-specific protocol; they do not replace method validation for a particular lot or assay.
Related Research Materials
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Buy Bulk MOTS-c for Research
Bulk Peptides supplies bulk MOTS-c to institutional laboratories, CROs, and research facilities across the United States. Every lot is characterized by reverse-phase HPLC at 220 nm and confirmed by electrospray ionization mass spectrometry before shipping. A lot-specific Certificate of Analysis documents both results for your records.
Bulk MOTS-c is available in the catalog sizes above. A minimum inquiry quantity of 10 vials applies; contact us for larger requirements or custom synthesis quotes. All products are for laboratory research use only (RUO) — not for human or veterinary use.
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