Bulk TB-500 (Thymosin Beta-4)
thymosin beta-4 and actin-regulation research research material, supplied as a lyophilized reference standard. >=99% by HPLC.
Available Sizes & Pricing
| Size | Price per vial (USD) |
|---|---|
| 10 mg | $69.95 |
A minimum inquiry quantity of 10 vials applies across requested products. Inquire for bulk purchase or larger lot quantities →
Bulk TB-500 (Thymosin Beta-4) Specifications
| CAS Number | 77591-33-4 |
|---|---|
| Molecular Formula | C212H350N56O78S |
| Molecular Weight | 4963.5 g/mol |
| Purity | >=99% by HPLC |
| Storage | Store lyophilized material at -20 C. Avoid repeated freeze-thaw cycles after reconstitution. |
What Is TB-500 (Thymosin Beta-4)?
TB-500 (Thymosin Beta-4) is cataloged for controlled laboratory workflows focused on thymosin beta-4 and actin-regulation research. Its lot-specific analytical documentation should be reviewed alongside the receiving laboratory's established handling and assay-validation procedures. For laboratory research use only - not for human or veterinary use.
TB-500 (Thymosin Beta-4) Research Context
TB-500, a synthetic form of the ubiquitous actin-sequestering protein thymosin beta-4 (Tβ4), contains the central actin-binding LKKTETQ motif responsible for G-actin monomer sequestration. In cell biology research it is used to probe actin cytoskeletal dynamics, cortical actin reorganization, and cell-migration responses in wound-closure and scratch assays. The peptide's defined 43-amino-acid sequence enables side-by-side comparison with truncated fragments to map functional domains.
TB-500 binds monomeric G-actin in a 1:1 stoichiometry, maintaining a soluble actin pool available for rapid cytoskeletal remodeling. In scratch-assay models, exogenous Tβ4 application has been associated with increased lamellipodia formation and directed cell migration in keratinocyte and endothelial cell lines.
Study-Design Considerations
- Confirm reconstituted peptide concentration by absorbance at 205 nm or by amino-acid analysis, as TB-500 lacks aromatic residues for standard 280 nm quantification.
- Scratch-assay wound-closure experiments should include cytochalasin D controls to distinguish actin-dependent migration from passive gap closure due to cell proliferation.
Interpretation Limits
In vitro actin-binding and migration effects of exogenous Tβ4 are measured under simplified conditions that cannot fully replicate the intracellular protein environment or tissue context.
TB-500 (Thymosin Beta-4) Research Applications
- Actin-binding research
- Cell migration studies
- Angiogenesis pathway models
Source Records
Use the following scientific and compound-record sources when developing a laboratory-specific protocol; they do not replace method validation for a particular lot or assay.
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Buy Bulk TB-500 (Thymosin Beta-4) for Research
Bulk Peptides supplies bulk TB-500 (Thymosin Beta-4) to institutional laboratories, CROs, and research facilities across the United States. Every lot is characterized by reverse-phase HPLC at 220 nm and confirmed by electrospray ionization mass spectrometry before shipping. A lot-specific Certificate of Analysis documents both results for your records.
Bulk TB-500 (Thymosin Beta-4) is available in the catalog sizes above. A minimum inquiry quantity of 10 vials applies; contact us for larger requirements or custom synthesis quotes. All products are for laboratory research use only (RUO) — not for human or veterinary use.
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