Bulk GHK-Cu
copper-peptide and extracellular-matrix signaling research material, supplied as a lyophilized reference standard. >=99% by HPLC.
Available Sizes & Pricing
| Size | Price per vial (USD) |
|---|---|
| 50 mg | $39.95 |
| 100 mg | $59.95 |
A minimum inquiry quantity of 10 vials applies across requested products. Inquire for bulk purchase or larger lot quantities →
Bulk GHK-Cu Specifications
| CAS Number | See lot-specific COA |
|---|---|
| Molecular Formula | See lot-specific COA |
| Molecular Weight | See lot-specific COA |
| Purity | >=99% by HPLC |
| Storage | Store lyophilized material at -20 C. Avoid repeated freeze-thaw cycles after reconstitution. |
What Is GHK-Cu?
GHK-Cu is cataloged for controlled laboratory workflows focused on copper-peptide and extracellular-matrix signaling. Its lot-specific analytical documentation should be reviewed alongside the receiving laboratory's established handling and assay-validation procedures. For laboratory research use only - not for human or veterinary use.
GHK-Cu Research Context
GHK-Cu is a naturally occurring tripeptide-copper complex (Gly-His-Lys·Cu²⁺) found in human plasma. In controlled laboratory studies it has been investigated for its capacity to influence extracellular-matrix gene expression, stimulate matrix metalloproteinase activity, and modulate cell-migration behavior in dermal fibroblast models. Its copper-chelating geometry distinguishes it mechanistically from copper-free peptide controls and makes it a useful probe for dissecting copper-dependent versus peptide-specific signaling.
The Gly-His-Lys sequence forms a square-planar coordination complex with Cu²⁺ through the N-terminal amine, the imidazole nitrogen, and a backbone amide nitrogen. This complex is proposed to facilitate copper delivery to copper-dependent enzymes (e.g., lysyl oxidase, superoxide dismutase), influencing collagen and elastin crosslinking pathways in fibroblast assays.
Study-Design Considerations
- Copper-free control wells using apo-GHK (without Cu²⁺) are essential to distinguish peptide-sequence effects from copper-ion effects in gene-expression or migration assays.
- Working concentrations above 10 µM may introduce copper cytotoxicity artifacts in sensitive cell lines; conduct a viability pre-screen across the planned concentration range.
Interpretation Limits
Extracellular-matrix findings from 2D fibroblast monolayer models may not reflect the signaling complexity present in 3D tissue or whole-organism contexts.
GHK-Cu Research Applications
- Copper-peptide binding studies
- Cell migration models
- Extracellular-matrix research
Source Records
Use the following scientific and compound-record sources when developing a laboratory-specific protocol; they do not replace method validation for a particular lot or assay.
Related Research Materials
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Buy Bulk GHK-Cu for Research
Bulk Peptides supplies bulk GHK-Cu to institutional laboratories, CROs, and research facilities across the United States. Every lot is characterized by reverse-phase HPLC at 220 nm and confirmed by electrospray ionization mass spectrometry before shipping. A lot-specific Certificate of Analysis documents both results for your records.
Bulk GHK-Cu is available in the catalog sizes above. A minimum inquiry quantity of 10 vials applies; contact us for larger requirements or custom synthesis quotes. All products are for laboratory research use only (RUO) — not for human or veterinary use.
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