Bulk Semaglutide (GLP-1)
GLP-1 receptor signaling and incretin research research material, supplied as a lyophilized reference standard. >=98% by HPLC.
Available Sizes & Pricing
| Size | Price per vial (USD) |
|---|---|
| 10 mg | $79.95 |
A minimum inquiry quantity of 10 vials applies across requested products. Inquire for bulk purchase or larger lot quantities →
Bulk Semaglutide (GLP-1) Specifications
| CAS Number | 910463-68-2 |
|---|---|
| Molecular Formula | C187H291N45O59 |
| Molecular Weight | 4113.6 g/mol |
| Purity | >=98% by HPLC |
| Storage | Store lyophilized material at -20 C. Avoid repeated freeze-thaw cycles after reconstitution. |
What Is Semaglutide (GLP-1)?
Semaglutide (GLP-1) is cataloged for controlled laboratory workflows focused on glp-1 receptor signaling and incretin research. Its lot-specific analytical documentation should be reviewed alongside the receiving laboratory's established handling and assay-validation procedures. For laboratory research use only - not for human or veterinary use.
Semaglutide (GLP-1) Research Context
Semaglutide is a GLP-1 receptor agonist peptide modified with a C18 fatty-diacid linker to extend plasma half-life through albumin association. As a research reference standard it provides a well-characterized monoselective GLP-1R tool compound whose pharmacological properties have been extensively described in the peer-reviewed literature. It is routinely used in receptor competition binding assays and cAMP accumulation models in GLP-1R-transfected cells.
Semaglutide activates GLP-1R through Gs coupling, elevating intracellular cAMP and downstream PKA activity. Its fatty-acid modification reduces aqueous solubility relative to unmodified GLP-1 analogs, which is an important variable to control in dilution-series experiments.
Study-Design Considerations
- Prepare stock solutions in DMSO or dilute aqueous acid (0.1% acetic acid) before aqueous dilution to avoid aggregation at higher concentrations.
- Include a native GLP-1(7-36)NH₂ comparator in binding-competition assays to benchmark receptor selectivity against the endogenous ligand.
Interpretation Limits
In vitro GLP-1R activation data do not model the complex pharmacokinetic and tissue-distribution properties observed in vivo and should not be used to infer clinical equivalence.
Semaglutide (GLP-1) Research Applications
- GLP-1 receptor activation assays
- Incretin pathway research
- Comparative metabolic models
Source Records
Use the following scientific and compound-record sources when developing a laboratory-specific protocol; they do not replace method validation for a particular lot or assay.
Related Research Materials
- Bulk Tirzepatide (GLP-2) — dual GIP and GLP-1 receptor pharmacology research material, supplied as a lyophilized reference standard. >=99% by HPLC.
- Bulk Retatrutide (GLP-3) — triple incretin receptor pharmacology research material, supplied as a lyophilized reference standard. >=99% by HPLC.
Buy Bulk Semaglutide (GLP-1) for Research
Bulk Peptides supplies bulk Semaglutide (GLP-1) to institutional laboratories, CROs, and research facilities across the United States. Every lot is characterized by reverse-phase HPLC at 220 nm and confirmed by electrospray ionization mass spectrometry before shipping. A lot-specific Certificate of Analysis documents both results for your records.
Bulk Semaglutide (GLP-1) is available in the catalog sizes above. A minimum inquiry quantity of 10 vials applies; contact us for larger requirements or custom synthesis quotes. All products are for laboratory research use only (RUO) — not for human or veterinary use.
See HPLC & COA quality standards · Shipping & payment information · Full bulk peptides catalog