Bulk Retatrutide (GLP-3)
triple incretin receptor pharmacology research material, supplied as a lyophilized reference standard. >=99% by HPLC.
Available Sizes & Pricing
| Size | Price per vial (USD) |
|---|---|
| 10 mg | $99.95 |
| 20 mg | $174.95 |
| 30 mg | $249.95 |
| 60 mg | $459.95 |
A minimum inquiry quantity of 10 vials applies across requested products. Inquire for bulk purchase or larger lot quantities →
Bulk Retatrutide (GLP-3) Specifications
| CAS Number | 2381272-15-5 |
|---|---|
| Molecular Formula | C224H358N68O65S |
| Molecular Weight | 4969.8 g/mol |
| Purity | >=99% by HPLC |
| Storage | Store lyophilized material at -20 C. Avoid repeated freeze-thaw cycles after reconstitution. |
What Is Retatrutide (GLP-3)?
Retatrutide (GLP-3) is cataloged for controlled laboratory workflows focused on triple incretin receptor pharmacology. Its lot-specific analytical documentation should be reviewed alongside the receiving laboratory's established handling and assay-validation procedures. For laboratory research use only - not for human or veterinary use.
Retatrutide (GLP-3) Research Context
Retatrutide is a synthetic acylated peptide designed to engage three distinct incretin-related receptors—GLP-1R, GIPR, and the glucagon receptor—in a single molecular scaffold. In controlled in vitro settings it has been used to probe simultaneous multi-receptor activation and downstream cAMP accumulation in transfected cell lines. Its triple-agonist architecture distinguishes it from earlier dual-agonist reference standards and makes it a useful comparator when mapping receptor cross-talk in metabolic signaling panels.
In receptor-binding and cell-based assays, retatrutide activates GLP-1R, GIPR, and GCGR through Gs-coupled cAMP generation. Relative potency at each receptor can be differentiated using selective antagonists, enabling mechanistic dissection of multi-receptor contributions in transfected or native cell systems.
Study-Design Considerations
- Reconstitute in aqueous buffer with a physiological pH range (7.0–7.4) and verify solubility before dilution series, as acylated peptides can aggregate at low pH.
- Include single-receptor reference agonists alongside retatrutide in parallel wells to attribute observed signals to specific receptor subtypes.
Interpretation Limits
In vitro receptor-activation data obtained with this reference standard cannot be extrapolated to predict in vivo pharmacology, systemic exposure, or any clinical outcome.
Retatrutide (GLP-3) Research Applications
- GLP-1, GIP, and glucagon receptor assays
- Comparative incretin signaling
- Cell-based metabolic pathway studies
Source Records
Use the following scientific and compound-record sources when developing a laboratory-specific protocol; they do not replace method validation for a particular lot or assay.
Related Research Materials
- Bulk Tirzepatide (GLP-2) — dual GIP and GLP-1 receptor pharmacology research material, supplied as a lyophilized reference standard. >=99% by HPLC.
- Bulk Semaglutide (GLP-1) — GLP-1 receptor signaling and incretin research research material, supplied as a lyophilized reference standard. >=98% by HPLC.
Buy Bulk Retatrutide (GLP-3) for Research
Bulk Peptides supplies bulk Retatrutide (GLP-3) to institutional laboratories, CROs, and research facilities across the United States. Every lot is characterized by reverse-phase HPLC at 220 nm and confirmed by electrospray ionization mass spectrometry before shipping. A lot-specific Certificate of Analysis documents both results for your records.
Bulk Retatrutide (GLP-3) is available in the catalog sizes above. A minimum inquiry quantity of 10 vials applies; contact us for larger requirements or custom synthesis quotes. All products are for laboratory research use only (RUO) — not for human or veterinary use.
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